1. Define toxicology.
2. Define environmental toxicology.
3. What is the difference between environmental toxicology and ecotoxicology?
4. What knowledge can be gained from dose-response relationships?
5. Why are the shape and slope of a dose-response curve important?
6. What role do shape and slope play in environmental toxicology?
7. Explain LD50.
8. Explain LD10.
Review the following chart and answer the following questions:
1. Based on LD10, which toxicant is more potent? Why?
2. Based on LD50, which toxicant is more potent? Why?
3. At what dose do these toxicants have the same percentage lethality?
Toxicology Chart
|
Dose |
Toxicant A |
Toxicant B |
|
mg/kg |
% lethality |
% lethality |
|
0.01 |
20 |
25 |
|
0.05 |
25 |
30 |
|
0.1 |
30 |
35 |
|
0.5 |
40 |
40 |
|
1 |
45 |
50 |
|
5 |
55 |
65 |
|
10 |
60 |
70 |
|
50 |
70 |
85 |
|
100 |
75 |
95 |
|
500 |
95 |
105 |
|
1,000 |
100 |
107 |
|
5,000 |
105 |
108 |
|
10,000 |
107 |
109 |
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